Whole Plant 

   Cannabis flower contains hundreds of molecules that have the ability to directly affect
our minds and bodies. Cannabinoids, terpenes, and flavonoids bind to different cells, and
receptors throughout our bodies, influencing our experience with cannabis. These
phytochemicals share similarities in medicinal value, as well as in how we perceive cannabis
through our senses. The many similarities suggest that these phytochemicals may interact or
have synergy with each other. Dr. John McPartland, a well- known cannabis researcher has
stated that “cannabis is polypharmaceutical” , meaning diversely medicinal and the “synergy
arises from interactions between its multiple components.”

   A few popular terms associated with this phytochemical synergy are “entourage effect”,
and “ensemble effect”. “Entourage effect” was the first term coined to describe the
relationship between the phytochemicals and their combined effect on the body. The word
entourage suggests one component, generally THC, is the main attraction, while the others are
there to support. The term “ensemble effect” has recently become popularized as it suggests
the view that all of the phytochemicals share equal importance in our experience with

   While studies are still very limited, synergy has been observed between cannabinoids
and terpenes in different combinations.
   + Pinene counteracts the memory loss and compromised cognition associated with high
    levels of THC
   + Pinene, Myrcene, and Caryophyllene together calm anxiety
   + CBD reduces the anxiety associated with high levels of THC
   + THC combined with CBD can be a strong sedative
   + Linalool, Limonene, with CBG is showing promise as a treatment for MRSA
   + Linalool, Limonene are known to enhance the effects of CBD and the combination is
   being studied as a treatment for acne
   + Linalool, Myrcene, and Pinene combined potentiate the effect of sedative
   cannabinoids showing promise as a sleep aid
   + Caryophyllene, Myrcene, and Pinene combined have value in addiction treatment
   + Myrcene reduces blood-brain barrier resistance, easing the transport of cannabinoids
   and flavonoids
   + THC combined with CBD and CBC is a powerful antidepressant

   Dr. Russo, a neurologist who has long studied cannabis and its chemical compounds,
explains that both cannabinoids and terpenes increase blood flow, enhance cortical activity,
and kill respiratory pathogens, as well as influence each other’s mechanisms. He suggests there
could be synergy between the two with respect to treating pain, inflammation, depression,
anxiety, addiction, epilepsy, cancer, and fungal and bacterial infections. From isolated studies,
we know that many cannabinoids, terpenes, and flavonoids have been found to offer relief
from pain and inflammation. These phytochemicals all affect different receptors, and cellular
pathways, targeting pain and inflammation at multiple sources. It would only make sense to
assume that consuming a combination of these three types of phytochemicals would provide
the most effective relief from pain. Most of the research on the hundreds of chemical
compounds found in cannabis has been studies of individual isolated cannabinoids, terpenes, or
flavonoids. Studies of different phytochemical combinations, as they appear naturally in
cannabis flower, are extremely limited, due to federal prohibition of cannabis. This kind of
research could really broaden our understanding of the special relationship humans have had
with cannabis for many thousands of years.

   All that we know about cannabis’s powerful phytochemicals is the result of studying
them in isolation, however it is rare that we consume a cannabinoid, terpene, or flavonoid
alone. It is much more common to consume multiple phytochemicals at one time. The easiest
way to access the phytochemical diversity of cannabis is to consume unadulterated cannabis
flower. The term “whole plant medicine” is a reference to cannabis flower and cannabis

products that contain the full spectrum of therapeutic phytochemicals that cannabis has to
offer. Just like eating whole fruits and vegetables is assumedly more nutritionally beneficial
than taking over the counter vitamins, consuming the hundreds of diverse phytochemicals
found in whole plant cannabis assumedly provides greater benefit than an isolated cannabinoid
or terpene. The magic of cannabis lies in the synergy between the phytochemicals.