Pictured: Hops @pixabay

Humulene is a close chemical cousin of Caryophyllene, differing in molecular structure. It is the characteristic terpene in hops, and is also naturally found in sage, balsam fir trees, coriander, ginseng, and ginger. In cannabis, Humulene often takes a backseat to the aromas of other terpenes, offering a more subtle earthy, herbal, and floral scent. Our third party terpene testing has shown, when a strain has higher levels of Humulene it almost always has high levels of
Caryophyllene. Even though they are chemical cousins, Humulene does not have activity at our CB2 receptors like Caryophyllene. Despite the lack of CB2 activity, Humulene is able to target inflammation both topically and internally. Humulene has shown the ability to reduce the inflammation and swelling characteristic of a histamine (allergic) reaction. As a pain reliever,        Humulene is active orally, topically, and via inhalation. Its cancer fighting power lies in Humulene’s ability to produce a dose and time dependent decrease in glutathione (an antioxidant) and increase in ROS (reactive oxygen species) in tumor cells. The oxidative stress caused by a rapid increase in ROS to toxic levels, and a decrease in antioxidants can lead to the damage and death of cancer cells. Significant evidence suggests that the presence of Caryophyllene potentiates the cancer fighting abilities of Humulene. There are many anecdotal accounts of Humulene acting as an anorectic or appetite suppressing agent, suggesting it has the potential to aid in weight loss. This may have a connection with the terpene’s ability to lower blood sugar levels. More research is needed concerning Humulene and its effect on the appetite.

Higher Grade strains with a relatively high percentage of Humulene: